. 2018 Nov 30;6:91–99. doi: 10.1016/j.toxrep.2018.11.015

Table 1.

Serum markers and urinary biomarkers levels on Day 4 and Day 8 (n = 10).

Day	Treatment groups		Urinary biomarkers (ng/mg creatinine)				Serum markers (mg/dL)
Day	Treatment groups		Clusterin	Kim-1	Cystatin C	NGAL	Creatinine	BUN
4	Control	Mean	39.44	0.29	0.57	41.69	0.57	17.90
	Control	SD	6.49	0.06	0.22	29.29	0.05	2.48
	Gentamicin 30 mg/kg	Mean	74.63^**	0.32	0.94	45.41	0.55	17.52
	Gentamicin 30 mg/kg	SD	24.87	0.11	0.46	15.94	0.09	1.98
	Gentamicin 100 mg/kg	Mean	148.95^***	0.80^***	2.03^***	80.11^*	0.63	20.28
	Gentamicin 100 mg/kg	SD	34.75	0.32	1.19	40.75	0.06	2.70
8	Control	Mean	43.10	0.30	0.63	43.34	0.59	18.46
	Control	SD	13.20	0.10	0.27	20.13	0.07	2.39
	Gentamicin 30 mg/kg	Mean	336.34^***	0.96	1.67	97.11	0.59	18.93
	Gentamicin 30 mg/kg	SD	182.31	0.73	0.91	46.73	0.06	1.67
	Gentamicin 100 mg/kg	Mean	402.14^***	4.39^***	20.19^***	395.03^***	1.99^***	103.18^***
	Gentamicin 100 mg/kg	SD	147.80	1.49	4.98	352.26	0.86	36.31

	Fold Change as compared to control on Day 4
	Gentamicin 30 mg/kg		1.9	1.1	1.7	1.1	1.0	1.0
	Gentamicin 100 mg/kg		3.8	2.8	3.6	1.9	1.1	1.1
	Fold Change as compared to control on Day 8
	Gentamicin 30 mg/kg		7.8	3.2	2.6	2.2	1.0	1.0
	Gentamicin 100 mg/kg		9.3	14.6	31.9	9.1	3.4	5.6

One way ANOVA followed by Dunnett’s multiple comparison test (P < 0.05).

^**

One way ANOVA followed by Dunnett’s multiple comparison test (P < 0.01).

^***

One way ANOVA followed by Dunnett’s multiple comparison test (P < 0.001); Kim-1=kidney injury molecule; NGAL = Neutrophil gelatinase associated lipocalin; BUN = blood urea nitrogen.