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. 2018 Dec 17;6:227. doi: 10.1186/s40168-018-0611-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Esophageal community types are functionally distinct. a nMDS plot of Bray–Curtis resemblance generated from square root-transformed KEGG pathway (level 3) relative abundances (generated using HUMAnN2). Clusters from HCA of shotgun data (MetaPhlan2) were overlayed onto the nMDS plot. All available samples were utilized in this analysis. b PERMANOVA across shotgun HCA clusters of Bray–Curtis resemblance generated from square root-transformed KEGG pathway relative abundances. ANOSIM at KEGG pathway level 3 generated a sample statistic of 0.46 and P = 0.001. c KEGG pathways identified using LEfSe analysis to be differentially abundant across each community type. All available samples within each cluster were utilized in this analysis. Blue, cluster 1; green, cluster 2; red, cluster 3. d MetaCyc pathways identified using LEfSe analysis to be differentially abundant across each community type. A full list of pathway names can be found in Additional file 1.14. All available samples within each cluster were utilized in this analysis. ANOSIM for MetaCyc pathways generated a sample statistic of 0.41 and P = 0.001. Blue, cluster 1; green, cluster 2; red, cluster 3