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. 2018 Dec 17;16:361. doi: 10.1186/s12967-018-1726-x

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Pathway analysis of EMI-related circRNAs and genes. a, b GO analysis of all 663 upregulated genes in EMI versus non-EMI AML samples. The activated biological processes related to EMI were principally involved in cell–cell crosstalk, including cell adhesion (GO:0030155; GO:0007155), migration (GO:0016477; GO:0030334), signal transduction (GO:0009966; GO:0007165) and cell–cell communication (GO:0010646; 0007154). The X-axis represents the ratio of enriched differential genes (a, b). The Y-axis shows the names of process that were significantly enriched (a, b). The size of each node represents the number of enriched differential genes, and the p-values are indicated by color changes from red to purple (b). Downregulated genes were not associated with specific EMI-related processes