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. 2018 Dec 17;6:226. doi: 10.1186/s40168-018-0605-2

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Mixture model of contaminants and non-contaminants in MGS experiments. Contaminant DNA is expected to be present in approximately equal and low concentrations across samples, while sample DNA concentrations can vary widely. As a result, the expected frequency of contaminant DNA varies inversely with total sample DNA concentration (red), while the expected frequency of non-contaminant DNA does not (blue)