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. 2018 Nov 19;115(49):12447–12452. doi: 10.1073/pnas.1810647115

Fig. 3.

Fig. 3.

SIR-mediated compaction requires the interaction between Sir3 and Sir4. (A) EMSA of Sir3 titrated onto WT and H4K16Q arrays in the absence or presence of Sir2/4I1311N. (B and C) vHW plots of Sir3, Sir2–4I1311N, and Sir3 and Sir2–4I1311N complex added to WT and H4K16Q arrays. (D) 2DSA/GA-MC modeling results of the sedimentation data in B and C. Numbers in brackets represent expected molecular masses. Numbers in parentheses are 95% confidence intervals. Stoichiometries upon addition of Sir3 and Sir2–4 are speculative.