Table 1.
Clinical Characteristics of the Discovery and Replication Samples
| Characteristicsa | Framingham Offspring N = 2,163 |
Framingham Gen 3 N = 2,946 |
Rotterdam Study N = 414 |
|---|---|---|---|
| Women, n (%) | 1,198 (55) | 1,564 (53) | 215 (52) |
| Age, year | 67 ± 9 | 47 ± 9 | 59 ± 8 |
| Clinical biological age, year | 67 ± 11 | 47 ± 12 | 59 ± 10 |
| ∆Age, year | 0 ± 6.2 | 0 ± 8.1 | 0 ± 6.3 |
| Clinical Variables in Biologic Age | |||
| Systolic blood pressure, mm Hg | 133 ± 18 | 118 ± 15 | 132 ± 19 |
| Forced Expiratory Volume at 1 s (L) | 2.6 ± 0.8 | 3.6 ± 0.8 | 3.2 ± 0.9 |
| Total cholesterol, mg/dL | 186 ± 37 | 187 ± 35 | 212 ± 39 |
| Glucose, mg/dL | 107 ± 22 | 96 ± 18 | 101 ± 16 |
| C-reactive protein, mg/dL | 3.2 ± 6.4 | 2.6 ± 4.1 | 2.3 ± 3.1 |
| Creatinine, mg/100 mL | 0.9 ± 0.3 | 0.9 ± 0.2 | 0.9 ± 0.2 |
| BMI kg/m2 | 28.4 ± 5.3 | 28.0 ± 5.9 | 27.8 ± 4.5 |
| Current smoking, n (%) | 167 (8) | 297 (10) | 98 (24) |
| Diabetes mellitus, n (%) | 292 (14) | 137 (5) | 35 (8) |
| Hypertension treatment, n (%) | 1037 (48) | 483 (16) | 2 (0.5) |
| Lipid treatment, n (%) | 926 (43) | 462 (16) | 102 (25) |
| Cardiovascular disease, n (%) | 160 (7) | 28 (1) | 32 (8) |
| Cancer, n (%) | 344 (16) | 131 (4) | 36 (9) |
Note: ∆Age = Clinical biologic age – chronologic age.
aCharacteristics are represented by mean ± SD or n (%).