Table 2.
Plasma Protein and Polypeptide Concentrations Measured in 160 Healthy Adults, by Sex-Specific Tertiles of Age
| Analyte† | All Participants | Men | Women | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low | Middle | High | p‡ | Low | Middle | High | p‡ | Low | Middle | High | p‡ | |
| GDF8 prodomain | 11.1 (3.2) | 11.1 (3.7) | 14.3. (14.6) | .10 | 11.2 (3.1) | 11.4 (3.7) | 16.9 (20.2) | .15 | 11.1 (3.4) | 10.7 (3.7) | 11.7 (3.4) | .56 |
| GDF8 mature protein | 26.7 (7.9) | 28.4 (7.2) | 26.1 (6.1) | .21 | 27.4 (7.4) | 28.4 (7.4) | 26.4 (6.0) | .57 | 26.0 (8.3) | 28.4 (7.2) | 25.7 (6.2) | .35 |
| GDF11 prodomain | 17.3 (9.4) | 21.3 (8.9) | 23.3 (9.9) | .02 | 18.5 (10.4) | 19.9 (8.6) | 21.5 (9.9) | .62 | 15.9 (8.2) | 23.2 (9.2) | 25.0 (9.7) | .008 |
| GDF11 mature protein | 16.5 (12.4) | 15.2 (7.3) | 18.9 (5.2) | .09 | 15.7 (14.6) | 14.0 (6.4) | 17.6 (4.2) | .38 | 17.2 (10.0) | 16.4 (8.0) | 20.1 (5.9) | .22 |
| FST315 | 29.2 (7.1) | 28.9 (6.7) | 35.7 (9.6) | <.001 | 26.5 (5.5) | 28.5 (5.6) | 34.3 (6.3) | <.001 | 31.8 (7.6) | 29.3 (7.7) | 37.1 (12.0) | .01 |
| FST303 | 86.4 (78.2) | 79.4 (85.6) | 106.4 (120.3) | .35 | 100.3 (94.8) | 67.3 (57.9) | 126.7 (160.3) | .18 | 71.3 (53.0) | 92.5 (107.8) | 86.1 (54.8) | .60 |
| WFIKKN1 | 41.4 (9.1) | 35.8 (10.8) | 37.5 (9.3) | .01 | 41.7 (8.7) | 37.6 (11.1) | 36.2 (9.7) | .11 | 41.0 (9.8) | 33.9 (10.3) | 38.7 (8.9) | .03 |
| WFIKKN2 | 29.5 (11.8) | 42.0 (21.9) | 36.4 (12.0) | <.001 | 27.9 (10.8) | 37.7 (18.7) | 36.3 (11.3) | .03 | 31.1 (12.8) | 46.3 (24.3) | 36.5 (12.9) | .01 |
†Concentration in ng/mL, showing mean (SD).
‡Comparison across tertiles using analysis of variance (ANOVA).