Table 4.
Multivariable Linear Regression Models of the Relationship Between Plasma GDF8 Mature Protein and Plasma GDF11 Mature Protein and Their Circulating Antagonists With Knee Strength in Healthy Adults
| Peptide or Protein | β | SE | p |
|---|---|---|---|
| (a) Multivariable models for GDF8 and GDF11, respectively, with knee strength, adjusted by age, sex, and physical activity | |||
| GDF8 mature | −.08 | 0.06 | .15 |
| GDF11 mature | .04 | 0.04 | .38 |
| (b) Multivariable model for GDF8 and circulating antagonists with knee strength, adjusted by age, sex, and physical activity | |||
| GDF8 mature | −.05 | 0.07 | .43 |
| GDF8 prodomain | .002 | 0.04 | .96 |
| FST315 | −.14 | 0.06 | .02 |
| FST303 | −.003 | 0.004 | .45 |
| WFIKKN1 | −.02 | 0.06 | .69 |
| WFIKKN2 | .03 | 0.04 | .37 |
| (c) Multivariable model for GDF11 and circulating antagonists with knee strength, adjusted by age, sex, and physical activity | |||
| GDF11 mature | .10 | 0.08 | .18 |
| GDF11 prodomain | .07 | 0.06 | .27 |
| FST315 | −.18 | 0.08 | .02 |
| FST303 | .005 | 0.01 | .45 |
| WFIKKN1 | −.18 | 0.07 | .02 |
| WFIKKN2 | .06 | 0.05 | .30 |
| (d) Multivariable model for GDF8 and GDF11 and their circulating antagonists with knee strength, adjusted by age, sex, and physical activity | |||
| GDF8 mature | −.10 | 0.08 | .22 |
| GDF8 prodomain | .001 | 0.05 | .98 |
| GDF11 mature | .10 | 0.07 | .19 |
| GDF11 prodomain | .09 | 0.06 | .18 |
| FST315 | −.18 | 0.07 | .02 |
| FST303 | .005 | 0.01 | .50 |
| WFIKKN1 | −.16 | 0.07 | .03 |
| WFIKKN2 | .08 | 0.06 | .18 |