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. Author manuscript; available in PMC: 2018 Dec 18.
Published in final edited form as: J Immunotoxicol. 2017 Dec;14(1):235–240. doi: 10.1080/1547691X.2017.1394934

Figure 1.

Figure 1.

Nicotine effect on MAP and contractile response of mesenteric arteries following placental ischemia. RUPP or Sham animals were treated with nicotine or saline vehicle GD14–18 and MAP and contractile responses determined on GD19. (A) MAP increased in RUPP Vehicle (n= 7) compared to Sham Vehicle (n=7), but RUPP Vehicle was not significantly greater than RUPP animals treated with 1 mg nicotine/kg/day (RUPP Nicotine, n = 9). RUPP Nicotine was not significantly different from Sham Nicotine (n = 8) treated animals. *p < 0.05. (B) RUPP surgery significantly increased the active tension generated in response to 0.57 μM U46619 comparing RUPP Vehicle (n = 6) to Sham Vehicle (n = 6). In nicotine-treated animals, the contractile response to U46 was significantly higher in RUPP (n = 8) vs. Sham (n = 5). *p < 0.05.