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Nicotine does not affect the placental ischemia-induced increase in circulating C3a. C3a serum concentration is increased in RUPP Vehicle (n = 7) vs. Sham Vehicle (n = 7). Treatment with 1 mg nicotine/kg/day over a 5-day period did not attenuate the RUPP (n = 8) increase in C3a compared to Sham (n = 8). *p < 0.05.
