Table 1.
miRNAs that are up- or down-regulated in rectal cancer tissue compared to normal mucosa
| miRNA | log2(T/N) | p | q | miRNA cluster | CC |
|---|---|---|---|---|---|
| Up-regulated (20) | |||||
| hsa-miR-492 | 1.44 | 4.45E-20 | 2.92E-19 | N | |
| hsa-miR-223 | 0.99 | 9.75E-07 | 1.09E-06 | Y | |
| hsa-miRPlus-E1234 | 0.95 | 1.84E-14 | 6.06E-14 | N | |
| hsa-miR-135b | 0.93 | 2.83E-11 | 5.02E-11 | Y | |
| hsa-miR-542-5p | 0.90 | 6.05E-09 | 8.19E-09 | 424~503~542~450a-2/1~450b | N |
| hsa-miRPlus-E1245 | 0.86 | 1.01E-06 | 1.10E-06 | N | |
| hsa-miRPlus-E1079 | 0.76 | 3.32E-15 | 1.53E-14 | N | |
| SNORD12B | 0.69 | 1.39E-11 | 2.66E-11 | N | |
| hsa-miR-144 | 0.69 | 5.28E-05 | 1.06E-04 | 144~451 | N |
| hsa-miRPlus-E1077 | 0.68 | 4.03E-10 | 6.18E-10 | N | |
| hsa-miR-2110 | 0.65 | 1.95E-11 | 3.59E-11 | N | |
| hsa-miR-18a | 0.65 | 5.80E-08 | 7.21E-08 | 17~18a~19a~20a~19b1~92a1 | Y |
| hsa-miR-17 | 0.54 | 1.90E-04 | 3.66E-04 | 17~18a~19a~20a~19b1~92a1 | Y |
| hsa-miR-675 | 0.59 | 6.95E-09 | 9.14E-09 | Y | |
| hsa-miR-584 | 0.59 | 1.11E-06 | 1.18E-06 | N | |
| hsa-miRPlus-A1027 | 0.57 | 5.59E-07 | 6.43E-07 | N | |
| hsa-miR-31 | 0.56 | 4.79E-09 | 6.67E-09 | Y | |
| hsa-miR-21 | 0.56 | 2.94E-06 | 3.08E-06 | Y | |
| hsa-miR-483-5p | 0.56 | 3.06E-07 | 3.70E-07 | N | |
| hsa-miR-652* | 0.52 | 1.63E-03 | 2.85E-03 | new | N |
|
| |||||
| Down-regulated (29) | |||||
| hsa-miR-375 | −1.47 | 8.88E-30 | 4.09E-28 | N | |
| hsa-miR-195 | −1.30 | 3.47E-22 | 3.99E-21 | 497~195 | Y |
| hsa-miR-378 | −1.21 | 5.68E-29 | 1.31E-27 | Y | |
| hsa-miR-215 | −1.08 | 1.72E-14 | 6.06E-14 | 194-1~215 | Y |
| hsa-miR-194 | −0.79 | 5.39E-13 | 1.24E-12 | 194-1~215/194-2~192 | Y |
| hsa-miR-192 | −1.06 | 3.84E-15 | 1.61E-14 | 194-2~192 | Y |
| hsa-miR-192* | −0.78 | 4.68E-14 | 1.35E-13 | 194-2~192 | Y |
| hsa-miR-143 | −0.98 | 2.41E-15 | 1.23E-14 | 143~145 | Y |
| hsa-miR-145 | −0.89 | 3.19E-21 | 2.45E-20 | 143~145 | Y |
| hsa-miR-29c | −0.98 | 3.11E-21 | 2.45E-20 | 29b-2~29c | N |
| hsa-miR-147b | −0.92 | 1.50E-23 | 2.29E-22 | N | |
| hsa-miR-190 | −0.88 | 3.89E-13 | 9.42E-13 | N | |
| hsa-miR-1 | −0.87 | 1.81E-18 | 1.04E-17 | 1-2~133a-1 | Y |
| hsa-miR-30c | −0.86 | 4.06E-12 | 8.89E-12 | 30e~30c-1 | Y |
| hsa-miR-30e | −0.72 | 6.80E-12 | 1.42E-11 | 30e~30c-1 | Y |
| hsa-miR-30b | −0.85 | 8.74E-12 | 1.75E-11 | 30d~30b | Y |
| hsa-miR-26b | −0.81 | 1.78E-08 | 2.28E-08 | N | |
| hsa-miR-342-3p | −0.80 | 2.84E-13 | 7.26E-13 | Y | |
| hsa-miR-26a | −0.77 | 6.19E-15 | 2.37E-14 | N | |
| hsa-miR-10b | −0.72 | 7.72E-11 | 1.23E-10 | Y | |
| hsa-miR-148a | −0.70 | 8.81E-10 | 1.27E-09 | N | |
| hsa-miR-100 | −0.70 | 4.88E-11 | 8.02E-11 | 100~let-7a-2 | Y |
| hsa-let-7a | −0.57 | 3.59E-06 | 3.67E-06 | 100~let-7a-2 | Y |
| hsa-let-7f | −0.63 | 1.39E-05 | 3.09E-05 | let-7a-1~let-7f-1~let-7d | Y |
| hsa-miR-200b | −0.69 | 4.77E-11 | 8.02E-11 | 200b~200a~429 | Y** |
| hsa-miR-429 | −0.52 | 5.18E-06 | 5.18E-06 | 200b~200a~429 | Y** |
| hsa-miR-338-3p | −0.68 | 2.59E-13 | 7.00E-13 | 1250~338~3065~657 | N |
| hsa-miR-101 | −0.61 | 7.70E-10 | 1.14E-09 | 101-1~3671 | Y |
| hsa-miRPlus-E1141 | −0.60 | 1.64E-05 | 3.52E-05 | N | |
The 20 most up- and the 29 most down-regulated microRNAs (and one snoRNA) in rectal cancer (T) compared to normal adjacent tissue (N) are listed. Inclusion criteria: Var>0.2, |log2(T/N)|>0.5, p<0.001. The log-fold change, p-value of the two-sided t-test, and the q-value (FDR) for each microRNA are listed, as well as the microRNA cluster, where relevant. miR-652* is a new microRNA, not yet registered in miRBase. The CC column to the right indicates if the microRNA has been identified as differentially expressed in colon cancer (Y, yes; N, no; Y**, yes, but in opposite direction). Bold miRNAs have been validated by qRT-PCR.