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. 2018 Sep 12;28(1):155–165. doi: 10.1093/hmg/ddy316

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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(A) Difference in methylation between time since individuals first ever smoked and never smokers. Adjusted for batch effect, cell count, age, sex, social class and maternal smoking during pregnancy. (B) Difference in methylation between time since individuals started weekly smoking and never smokers. Adjusted for batch effect, cell count, age, sex, social class and maternal smoking during pregnancy. (C) Difference in methylation between smoking intensity and never smokers. Adjusted for batch effect, cell count, age, sex, social class and maternal smoking during pregnancy. (D) Difference in methylation between number of cigarettes ever smoked and never smokers. Adjusted for batch effect, cell count, age, sex, social class and maternal smoking during pregnancy.