Table 1.
Multivariate Cox regression analyses of CSS in SEER cohort.
| Variable | Overall | Pairwise | ||
|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | |
| T stage | < 0.001 | … | … | |
| T1 | Reference | |||
| T2 | 1.384 (1.298–1.475) | < 0.001 | ||
| T3 | 2.717 (2.567–2.876) | < 0.001 | ||
| T4a | 3.892 (3.657–4.143) | < 0.001 | ||
| T4b | 7.257 (6.812–7.731) | < 0.001 | ||
| Histology | < 0.001 | … | … | |
| Adenocarcinoma | Reference | |||
| Mucinous adenocarcinoma | 0.935 (0.903–0.967) | < 0.001 | ||
| Signet ring cell carcinoma | 1.462 (1.351–1.581) | < 0.001 | ||
| Tumor grade | < 0.001 | … | … | |
| Grade I | Reference | |||
| Grade II | 1.081 (1.039–1.125) | < 0.001 | ||
| Grade III | 1.292 (0.238–1.349) | < 0.001 | ||
| Grade IV | 1.270 (1.137–1.419) | < 0.001 | ||
| Unknown | 1.215 (1.143–1.291) | < 0.001 | ||
| Race | < 0.001 | … | … | |
| White | Reference | |||
| Black | 1.316 (1.276–1.357) | < 0.001 | ||
| Other | 0.908 (0.874–0.944) | < 0.001 | ||
| Unknown | 0.352 (0.215–0.574) | < 0.001 | ||
| Gender | 0.918 (0.900–0.936) | < 0.001 | … | … |
| Male | Reference | |||
| Female | 0.918 (0.900–0.936) | |||
| Tumor location | < 0.001 | … | … | |
| Cecum | Reference | |||
| Ascending colon | 0.949 (0.912–0.982) | 0.001 | ||
| Hepatic flexure | 1.016 (0.973–1.061) | 0.479 | ||
| Transverse colon | 0.947 (0.912–0.982) | 0.003 | ||
| Splenic flexure | 1.054 (1.003–1.106) | 0.036 | ||
| Descending colon | 1.049 (1.005–1.095) | 0.028 | ||
| Sigmoid Colon | 1.110 (1.081–1.139) | < 0.001 | ||
| Age at diagnosis (y) | < 0.001 | … | … | |
| ≤ 70 | Reference | |||
| >70 | 1.516 (1.485–1.546) | |||
| Year of diagnosis | < 0.001 | … | … | |
| 1988–1992 | Reference | |||
| 1993–1996 | 0.950 (0.919–0.981) | < 0.001 | ||
| 1997–2001 | 0.918 (0.892–0.945) | < 0.001 | ||
| 2002–2005 | 0.864 (0.839–0.889) | < 0.001 | ||
| Tumor size and node status | < 0.001 | … | … | |
| ≤ 2 cm, N0 | Reference | 1.000 (0.918–1.089) | 0.996 | |
| >2–4 cm, N0 | 1.087 (1.023–1.154) | 0.007 | 1.087 (1.014–1.165) | 0.018 |
| >4–6 cm, N0 | 1.068 (1.004–1.136) | 0.038 | 1.068 (0.996–1.145) | 0.064 |
| >6–7 cm, N0 | 1.035 (0.959–1.117) | 0.375 | 1.035 (0.954–1.124) | 0.409 |
| >7–8 cm, N0 | 1.000 (0.918–1.089) | 0.996 | Reference | |
| >8–9 cm, N0 | 1.080 (0.979–1.190) | 0.123 | 1.080 (0.975–1.196) | 0.139 |
| >9 cm, N0 | 1.134 (1.042–1.233) | 0.003 | 1.134 (1.037–1.239) | 0.006 |
| ≤ 2 cm, N+ | 2.122 (1.972–2.283) | < 0.001 | 2.122 (1.952–2.307) | < 0.001 |
| >2–4 cm, N+ | 2.589 (2.440–2.748) | < 0.001 | 2.590 (2.420–2.771) | < 0.001 |
| >4–6 cm, N+ | 2.622 (2.468–2.786) | < 0.001 | 2.623 (2.450–2.807) | < 0.001 |
| >6–7 cm, N+ | 2.628 (2.447–2.821) | < 0.001 | 2.628 (2.433–2.839) | < 0.001 |
| >7–8 cm, N+ | 2.700 (2.500–2.916) | < 0.001 | 2.697 (2.456–2.962) | < 0.001 |
| >8–9 cm, N+ | 2.696 (2.467–2.947) | < 0.001 | 2.701 (2.487–2.933) | < 0.001 |
| >9 cm, N+ | 2.915 (2.699–3.149) | < 0.001 | 2.916 (2.685–3.166) | < 0.001 |