Table 2.
Multivariate Cox regression analyses of CSS in FUSCC cohort.
| Variable | Overall | Pairwise | ||
|---|---|---|---|---|
| HR (95%) | P | HR (95%) | P | |
| Tumor location | 0.323 | … | … | |
| Right colon | Reference | |||
| Transverse colon | 0.829 (0.396–1.739) | 0.621 | ||
| Left colon | 1.022 (0.631–1.655) | 0.930 | ||
| Sigmoid colon | 0.715 (0.488–1.047) | 0.084 | ||
| Age (years) | 0.726 | … | … | |
| ≤ 70 | Reference | |||
| >70 | 1.082 (0.696–1.684) | |||
| Year of diagnosis | 0.643 | … | … | |
| 2008–2011 | Reference | |||
| 2012–2015 | 1.091 (0.755–1.576) | |||
| Gender | 0.900 | … | … | |
| Male | Reference | |||
| Female | 0.979 (0.705–1.361) | |||
| Neoadjuvant chemotherapy | 0.766 | … | … | |
| No | Reference | |||
| Yes | 0.872 (0.353–2.153) | |||
| Adjuvant chemotherapy | 0.044 | … | … | |
| No | Reference | |||
| Yes | 0.649 (0.426–0.989) | |||
| Tumor grade | 0.743 | … | … | |
| Well/moderately differentiated* | Reference | |||
| Poorly differentiated/undifferentiated* | 1.067 (0.726–1.567) | |||
| Histology | 0.525 | … | … | |
| Adenocarcinoma | Reference | |||
| Mucinous adenocarcinoma/ signet ring cell carcinoma | 1.153 (0.743–1.791) | |||
| T stage | 0.089 | … | … | |
| T1 | Reference | |||
| T2 | 1.337 (0.168–10.648) | 0.784 | ||
| T3 | 2.347 (0.318–17.325) | 0.403 | ||
| T4 | 3.019 (0.408–22.339) | 0.279 | ||
| Tumor size and nodal stage | < 0.001 | … | … | |
| 21–40 mm, N0 | Reference | 0.446 (0.263–0.756) | 0.003 | |
| 41–80 mm, N0 | 0.654 (0.375–1.142) | 0.135 | 0.292 (0.180–0.472) | < 0.001 |
| 21–40 mm, N+ | 1.875 (1.120–3.140) | 0.017 | 0.836 (0.555–1.258) | 0.390 |
| 41–80 mm, N+ | 2.243 (1.322–3.807) | 0.003 | Reference | |
Well/moderately differentiated*: : including well differentiated, well-moderately differentiated and well-moderately differentiated.
Poorly differentiated/undifferentiated*: : including poorly-moderately differentiated poorly differentiated, and undifferentiated.