Figure 1. The TNFR1 signaling pathway leading to NF-κB activation or cell death.

The TNF-bound TNFR1 is shown with the formation of complex I, leading to NF-κB activation on the left side, and formation of complex II, leading to cell death, on the right side. Ubiquitination modifications are shown, indicated as ‘M1’ for linear and ‘K63’ for lysine 63-linked ubiquitin chains. Proteins that were used as bait proteins in this study are indicated in blue.