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. 2018 Dec 14;10:6971–6984. doi: 10.2147/CMAR.S182852

Figure 6.

Figure 6

FOXM1 promotes proliferation in lung cancer cells.

Notes: (A) Pearson’s correlation was employed to analyze the correlation between PCNA and FOXM1 mRNA expression in 576 lung cancer samples in the available RNA-seq database downloaded from UCSC Xena (http://xena.ucsc.edu/; R=0.6311, P<0.0001). (B) The correlation between Ki-67 and FOXM1 mRNA expression in 576 lung cancer samples in the available RNA-seq database downloaded from UCSC Xena was measured by Pearson’s correlation (R=0.9147, P<0.001). (C, D) EdU assays were performed to evaluate the effect of CENPU knockdown on the growth of SPC-A1 and A549 cells. (E) Cell cycle analysis of SPC-A1 and A549 cells transfected with siFOXM1 or NC siRNA. ****P<0.0001; ***P<0.001 (mean ± SEM).

Abbreviations: EdU, 5-ethynyl-2’-deoxyuridine; FOXM1, Forkhead box protein M1; NC, negative control; PCNA, proliferating cell nuclear antigen; SEM, standard error of the mean; siFOXM1, FOXM1 siRNA.