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. 2018 Dec 4;9(95):36736–36749. doi: 10.18632/oncotarget.26314

Figure 2. Imiquimod treatment induces more severe psoriasis-like lesions in CRBPI-knockout mice.

Figure 2

(A) Back skin of wild-type (WT) and CRBPI-knockout (KO) mice after 6 days of treated control cream (vehicle) or imiquimod (IMQ); (B) daily scoring of erythema, scaling and thickness cumulative score (PASI) shows an early increase in imiquimod treated CRBPI-knockout skin compared to wild-type mice; (C-D) representative microscopic images of (C) vehicle control and (D) imiquimod-treated wild-type and CRBPI-knockout mouse skin, Haematoxylin&Eosin (H&E) staining; original magnification; 200X; (E-F) bar graphs showing semiquantitative evaluation of microscopic parameters of skin psoriasis in imiquimod-treated wild-type and CRBPI-knockout mice after six days. Results are expressed as mean values±SEM (n=8 mice per group); *p < 0.05; **p < 0.01;***p < 0.001 at Student’s t-test. Original magnification, 200X.