Figure 5:

Assessment of target space coverage to generate efficacy target hypotheses for phenotypic actives. A) Percentage of phenotypic assay actives (vertical axis) that could be associated with a potential efficacy target for each organism. The horizontal axis is the percentage of efficacy targets randomly selected for each screen, and each value is the average of 10 replicates. B) Adding CHEMGENIE annotations (green line) improves the percentage of bioactives for each screen with an efficacy target hypothesis, as compared to ALIS data alone (blue line). Shown are the results for M. tuberculosis, other organisms can be found in Supplementary Figure 2.