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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep 25;1863(12):1523–1531. doi: 10.1016/j.bbalip.2018.09.004

Table 1.

Top upregulated and downregulated mRNA transcripts in BAT from B6 mice (HF vs. HF-EPA), which were differentially regulated by EPA using QSeq software (P ≤ 0.05, fold change ≥2, RPKM ≥0.3). HF, high fat; HF-EPA, HF diet supplemented with EPA; RPKM, reads per kilo base per million mapped reads.

Gene Name RPKM HF RPKM HF-EPA Fold Change P value
Top upregulated genes
Klhl6 Kelch-Like Family Member 6 0.65 1.39 2.14 0.01
Sgk2 Serine/threonine-protein kinase 0.5 1.05 2.11 0
Pon1 Paraoxonase 1 8.43 17.8 2.11 0
Rrl41 Catalyze Protein Synthesis, Ribosomal Protein L41 5.48 11.49 2.1 0.01
Top downregulated genes
Notch1 translocation-associated Notch protein TAN-1 9.43 4.66 0.49 0.01
Casp7 Caspase 7 3.8 1.79 0.47 0.05
Hif1an Hypoxia Inducible Factor 1 Alpha Subunit Inhibitor 2.44 1.13 0.46 0
Gpd1 Glycerol-3-Phosphate Dehydrogenase 1 3.53 1.63 0.46 0.00
Crebbp CREB Binding Protein 4.57 2.04 0.45 0
Adora1 Adenosine A1 Receptor 19 8.25 0.43 0
Foxo1 Forkhead Box O1 4.65 1.95 0.42 0
Smad3 Smad Family Member 3 2.51 0.9 0.36 0
Igf2 Insulin Like Growth Factor 2 2.67 0.97 0.36 0.02
JUN Jun Proto-Oncogene 28.37 9.56 0.34 0
Inhbb Inhibin Beta B 1.57 0.52 0.33 0.01
Sp1 Sp1 Transcription Factor 2.96 0.95 0.32 0.01
Egr1 Early Growth Response 1 5.41 1.75 0.32 0
Tgfbr3 Transforming Growth Factor Receptor 3 5.52 1.64 0.3 0
Ncor2 Nuclear Receptor Corepressor 2 14.14 5.58 0.2 0.01