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. 2018 Dec 11;9:2866. doi: 10.3389/fimmu.2018.02866

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Copyright © 2018 Kamuyu, Tuju, Kimathi, Mwai, Mburu, Kibinge, Chong Kwan, Hawkings, Yaa, Chepsat, Njunge, Chege, Guleid, Rosenkranz, Kariuki, Frank, Kinyanjui, Murungi, Bejon, Färnert, Tetteh, Beeson, Conway, Marsh, Rayner and Osier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Specificity of KILchip v1.0. Positive and negative controls were used to confirm specificity. (A) High antibody reactivity was detected using malaria immune sera (MIS) and low or negligible reactivity was observed with malaria naïve sera (MNS). No reactivity was observed with the sample buffer with the exception of the technical controls. Blue, landmarks; green, commercial human IgG and yellow, printing buffer. (B) Antibody reactivity to selected well-characterized merozoite antigens AMA1, MSP2 (3D7), MSP3 (3D7), Rh5, and RIPR varied as expected in MIS (blue) and serum samples from adult residents of Kilifi. Kenya (red). High reactivity to AMA1, MSP2 (3D7), and MSP3 (3D7) and low reactivity to Rh5 and RIPR was observed in the serum samples. (C) Antibody reactivity to well-characterized antigens AMA1, MSP2, MSP3, Rh5, and RIPR were all low/negligible when tested in serum samples from Swedish residents.