Table I.
(No=68 patients) Age | Years | |
---|---|---|
Average | 6.5 | |
Median | 5.2 | |
Range | 0.9–17.6 | |
Gender | N° | % |
Male | 38 | 56 |
Female | 30 | 44 |
Immunophenotype | ||
B lineage | 58 | 85 |
T lineage | 10 | 15 |
Molecular genetics | ||
Negative | 47 | 69 |
BCR/ABL | 3 | 4 |
MLL/AF4 | 2 | 3 |
TEL/AML1 | 14 | 21 |
E2A/PBX1 | 2 | 3 |
Applied protocol | ||
ALL IC BFM 2002 | 39 | 57 |
ALL IC BFM 2009 | 29 | 43 |
Prednisolone response | ||
Good response | 61 | 90 |
Poor response | 7 | 10 |
Day 33 BM | ||
M1 | 67 | 98 |
M2 | 0 | 0 |
M3 | 1 | 2 |
Risk group | ||
Standard risk | 11 | 16 |
Intermediate risk | 47 | 69 |
High risk | 10 | 15 |
Outcome | ||
CR | 59 | 87 |
Relapse | 5 | 7 |
Death due to relapse | 4 | 6 |
Good prednisolone response: <1000 leukoblasts per mm3, poor prednisolone response: >1000 leukoblasts per mm3, BM: bone marrow, M1:<5% leukoblasts in BM, M2: ≥5% <25% leukoblasts, M3: ≥25% leukoblasts, CR: complete remission