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Thyroid regulation. Blue arrowheads/+ indicate stimulation, red arrowheads/- indicate inhibition. Hypothalamic TRH stimulates pituitary TSH (1) which stimulates thyroid hormone (predominantly FT4, but also FT3) production from the thyroid gland (2). FT4 and FT3 feedback negatively on the hypothalamus and pituitary, reducing levels of TRH and TSH (3). There is also negative feedback by TSH on its own production by the pituitary, i.e. TSH autoregulation (4).
