Fig. 3.

Holzapfel–Gasser–Ogden model sensitivity in the (a) circumferential and (b) axial directions, pre-elastase (solid lines) and postelastase (dashed lines) treatment. Pre- and post-treatment, the model was most sensitive to the collagen-associated nondimensional parameter—$c_2$ and the alignment angle-$\alpha$. Relative to control, post-treatment, the influence of the two parameters increased the most in both directions. Sensitivity indices were computed using optimized model parameters for averaged data (n = 8/group, for control and elastase).