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HnRNP A1 as a paradigm for RBP-mediated regulation of miRNA biogenesis in the nucleus. (A) Binding of hnRNP A1 to the TL of pri-mir-18a induces a structural rearrangement that results in enhanced Drosha processing. (B) Each RRM of hnRNP A1 recognizes an UAG motif in the TL of pri-mir-18a. (C) Binding of hnRNP A1 to the TL of pri-let-7 in differentiated cells outcompetes binding of the stimulatory factor, KSRP, resulting in decreased Drosha processing.
