Table 2. Predictors for survival in EAC patients presented as hazard ratios from multivariate cox regression model including Barrett’s phenotype, sex, age at diagnosis, Siewert classification and TNM stage in both cohorts and the tumor length in the Mayo cohort.
| Mayo | OCCAMS | |||||
|---|---|---|---|---|---|---|
| Total, N= 411 | Adjusted HR | 95% CI | Total, N= 1417 | Adjusted HR | 95% CI | |
| Barrett's Esophagus | ||||||
| Non-BE/IM | 207 | Reference | — | 783 | Reference | |
| BE/IM | 204 | 0.66 | 0.5 - 0.88 | 634 | 0.77 | 0.64-0.93 |
| Sex | ||||||
| Male | 350 | Reference | 1179 | 1.1 | 0.84-1.43 | |
| Female | 61 | 1.02 | 0.72-1.44 | 238 | Reference | |
| Age at diagnosis (years) | 411 | 1.02 | 1.01-1.04 | 1417 | 1.01 | 1.0-1.02 |
| Siewert Classification | ||||||
| 1 | 226 | Reference | — | 395 | Reference | |
| 2 | 166 | 0.75 | 0.56 - 1 | 501 | 0.85 | 0.7-10.5 |
| 3 | 0 | — | — | 175 | 0.92 | 0.7-1.2 |
| Tubular | 9 | 1.24 | 0.56 - 2.74 | — | — | — |
| Missing | 10 | 1.88 | 0.9 – 3.95 | |||
| TNM stage | ||||||
| I | 72 | Reference | — | 70 | Reference | |
| II | 92 | 2 | 1.22 - 3.44 | 662 | 3.25 | 1.44-7.33 |
| III | 154 | 3 | 1.8 – 5.1 | 480 | 6.25 | 2.77-14.13 |
| IV | 93 | 6.9 | 4 - 11.9 | 54 | 10.02 | 4.14-24.23 |
| Missing | 0 | — | — | |||
| Tumor length | ||||||
| 1-3 cm | 161 | Reference | ||||
| 3 cm<Length ? 6 cm | 129 | 0.82 | 0.57 - 1.18 | |||
| >6 cm | 69 | 1.1 | 0.7 - 1.63 | |||
| Missing | 52 | 1.1 | 0.68 - 1.7 | |||
| Log-Rank P<0.001 | Log-Rank P<0.001 | |||||