TABLE 1.
Category | Chemical | Food-Related Use | Selected Health Concerns |
---|---|---|---|
Indirect food additives | Bisphenols | Polycarbonate plastic containers Polymeric, epoxy resins in food and beverage cans |
Endocrine disruption11–18 Obesogenic activity,19–22 neurodevelopmental disruption23–26 |
Phthalates | Clear plastic food wrap Plastic tubing, storage containers used in industrial food production Multiple uses in food manufacturing equipment |
Endocrine disruption6,27–29 Obesogenic activity30–32 Oxidative stress,33,34 cardiotoxicity35,36 |
|
Perfluoroalkyl chemicals (PFCs) | Grease-proof paper and paperboard | Immunosupression,37,38 endocrine disruption,39–41 obesogenic activity,42 decreased birth wt43 | |
Perchlorate | Food packaging | Thyroid hormone disruption44–46 | |
Direct food additives | Nitrates and nitrites | Direct additive as preservative and color enhancer, especially to meats | Carcinogenicity,10,47,48 thyroid hormone disruption49,50 |