Table 4:
Benchmarking Test Case
1. Input | 2. Similarity Metric | 3. Prioritization |
---|---|---|
Tissue: Whole brain Brain regions Cell type-specific transcriptome Single cell transcriptome Genes: SNPs Differentially-expressed (top 50, 100 →500) Coexpression modules |
Correlation Enrichment (hypergeometric, Fischer’s, modified KS statistic) Pattern matching | Statistical methods Negative score vs absolute value of score Threshold (for example, −90 cut off) Median Combination of above |