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. Author manuscript; available in PMC: 2018 Dec 18.
Published in final edited form as: Psychopharmacology (Berl). 2018 Mar 1;235(6):1635–1662. doi: 10.1007/s00213-018-4855-2

Table 4:

Benchmarking Test Case

1. Input 2. Similarity Metric 3. Prioritization
Tissue:
Whole brain Brain regions Cell type-specific transcriptome Single cell transcriptome
Genes:
SNPs Differentially-expressed (top 50, 100 →500) Coexpression modules
Correlation Enrichment (hypergeometric, Fischer’s, modified KS statistic) Pattern matching Statistical methods Negative score vs absolute value of score Threshold (for example, −90 cut off) Median Combination of above
HHS Vulnerability Disclosure