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. 2018 Sep 12;82(4):e00015-18. doi: 10.1128/MMBR.00015-18

TABLE 4.

DNA viruses produce PAMPs and DAMPs during infection that activate inflammasomes and other sensors

Virus (type of genome) Inflammasome sensor(s) [activator(s)] [reference(s)]
Adenovirus (dsDNA) NLRP3 (cathepsin B, ROS) (208, 210, 212, 213)
Bovine herpesvirus 1 (dsDNA) IFI16 (viral DNA) (428), NLRP3 (unknown activator) (428)
Epstein-Barr virus (dsDNA) AIM2 (viral DNA) (200, 204), IFI16 (viral DNA) (429)
Hepatitis B virus (circular, partially dsDNA) AIM2 (viral DNA) (198, 203, 430, 431)
Herpes simplex virus (dsDNA) NLRP3 (ROS) (201, 205207), IFI16 (viral DNA) (205, 215)
Human bocavirus (ssDNA) NLRP3 (viral noncoding RNA) (432)
Human cytomegalovirus (dsDNA) AIM2 (viral DNA) (193)
Human papillomavirus 16 (dsDNA) AIM2 (viral DNA) (199)
Kaposi's sarcoma-associated herpesvirus (dsDNA) IFI16 (viral DNA) (433, 434)
Modified vaccinia virus Ankara (dsDNA) AIM2 (viral DNA) (201), NLRP3 (unknown activator) (168, 209)
Mouse cytomegalovirus (dsDNA) AIM2 (viral DNA) (162, 164)
Vaccinia virus (dsDNA) AIM2 (viral DNA) (31, 164)
Varicella-zoster virus (dsDNA) NLRP3 (unknown activator) (211)