TABLE 1.

Targets related to the static PGN structure/architecture

Target	Role(s)	Species	Effect(s) of target disruption	Reference(s)
Pal	A peptidoglycan-associated lipoprotein anchoring the outer membrane to PGN	B. cenocepacia	Reduction of virulence in a Galleria mellonella model of circa 90-fold; impaired host cell attachment and reduced stimulation of proinflammatory cytokine secretion	35
Lpp1, Lpp2	Structural murein lipoproteins	S. enterica serovar Typhimurium	Defective in invasion of macrophages and cytotoxicity for macrophages	39
Lpp	Braun's lipoprotein	Yersiniae	Decreased proinflammatory effects and mortality rates in murine/rat models of infection, decreased survival in murine macrophages, impaired tissue dissemination capacity, and elicitation of an inflammatory response	36–38, 42
YbiS, ErfK, YcfS	l,d-Transpeptidases participating in the anchoring of Braun's lipoproteins to PGN	S. enterica	Changes in PGN structure leading to higher resistance to bile salts	41