. 2018 Dec 18;13(12):e0208454. doi: 10.1371/journal.pone.0208454

Table 3. Change in DASS-42 stress subscale score from baseline to Week 4 and to Week 8.

mITT population	Mg–vit B6 combination (N = 132)	Mg (N = 132)
Change from baseline to Week 4^a (95% CI)	−8.94 (−10.22 to −7.65)	−7.58 (−8.86 to −6.30)
Difference between treatment arms	1.35 (−0.36 to 3.06), p = 0.1203
Change from baseline to Week 8^a (95% CI)	−12.44 (−13.83 to −11.05)	−11.72 (−13.10 to −10.33)
Difference between treatment arms	0.72 (−1.15 to 2.59), p = 0.4472
PP population	Mg–vit B6 combination (N = 117)	Mg (N = 116)
Change from baseline to Week 4^a ^b (95% CI)	−9.59 (−11.03 to −8.15)	−8.04 (−9.45 to −6.63)
Difference between treatment arms	1.55 (−0.33 to 3.43), p = 0.1056
Change from baseline to Week 8^a ^b (95% CI)	−13.26 (−14.81 to −11.71)	−12.21 (−13.73 to −10.68)
Difference between treatment arms	1.06 (−0.99 to 3.10), p = 0.3095

^aDifference from baseline in adjusted mean.

^bSubjects with subscale scores ≤18 baseline were excluded from the PP population.

CI, confidence interval; DASS, Depression Anxiety Stress Scale; mITT, modified intention-to-treat; Mg, magnesium; PP, per protocol; Vit B6, vitamin B6.