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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Biochem Pharmacol. 2018 Sep 25;158:27–34. doi: 10.1016/j.bcp.2018.09.024

Figure 3.

Figure 3.

Correlation of affinities and agonist potencies of substituted phenethylamines at 5-HT1A, 5-HT2A, 5-HT2B and 5-HT2C receptors. The linear regression for the data in each graph is shown. A. 5-HT1A affinities as measured with [3H]8-OH-DPAT binding vs 5-HT1A potencies as measured using [35S]GTPγS binding. Spearman r=0.19, p>0.05. B. 5-HT2A affinities as measured with [125I]DOI binding vs 5-HT2A potencies as measured using the IP-1 assay. Spearman r=0.72, p=0.01. C. 5-HT2B affinities as measured with [3H]5-HT binding vs 5-HT2B potencies as measured using the IP-1 assay. Spearman r=0.76, p<0.05. D. 5-HT2C affinities as measured with [125I]DOI binding vs 5-HT2C potencies as measured with IP-1 assay. Spearman r=0.67, p<0.05. Values for 2C-C, 2C-D, 2C-E, 2C-I, 2C-T-2 and DOC are from [23]