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. Author manuscript; available in PMC: 2018 Dec 18.
Published in final edited form as: Chem Res Toxicol. 2016 Aug 23;29(9):1504–1509. doi: 10.1021/acs.chemrestox.6b00172

Figure 4. PCB126 dose-dependently inhibits the activation of hepatic CREB1.

Figure 4.

Exposure to PCB126 results in reduced CREB phosphorylation (pCREB) on serine (S133) (A; center panel), but does not change the total protein levels of CREB (A; top panel). ACTB (A; bottom panel) represents the β-actin (control). The (B) ratio of pCREB/CREB were normalized to ACTB and found to be significantly decreased. Neuronal SK-N-MC cells stimulated with forskolin were used as a control for (A; left panel) specific recognition of pCREB during CREB activation.