Table 2.

HemoTypeSC^TM Detection Analysis by Hemoglobin Variant^a

Location	Hb	Sensitivityb		Specificityc		PPVd		NPVe
		TP/(TP+FN)	%	TN/(FP+TN)	%	TP/(TP+FP)	%	TN/(TN+FN)	%
Ghana	A	368/368	100.0	14/14	100.0	368/368	100.0	14/14	100.0
	S	49/50	98.0	331/332	99.7	49/50	98.0	331/332	99.7
	C	67/68	98.5	313/314	99.7	67/68	98.5	313/314	99.7
Martinique	A	45/45	100.0	1/1	100.0	45/45	100.0	1/1	100.0
	S	8/8	100.0	38/38	100.0	8/8	100.0	38/38	100.0
	C	5/5	100.0	41/41	100.0	5/5	100.0	41/41	100.0
USA	A	90/90	100.0	68/68	100.0	90/90	100.0	68/68	100.0
	S	95/95	100.0	63/63	100.0	95/95	100.0	63/63	100.0
	C	48/48	100.0	110/110	100.0	48/48	100.0	110/110	100.0
Total	A	503/503	100.0	83/83	100.0	503/503	100.0	83/83	100.0
	S	152/153	99.3	432/433	99.8	152/153	99.3	432/433	99.8
	C	120/121	99.2	464/465	99.8	120/121	99.2	464/465	99.8

^aTP = true positives, TN = true negatives, FP = false positives, FN = false negatives. Values presented represent the HemoTypeSC test results compared to the reference method, following ultimate adjudication of discordant results.

^bAny specimen that was either heterozygous or homozygous for each particular Hb variant was considered a true positive for that variant.

^cAny specimen that lacked each particular Hb variant was considered a true negative for that variant, regardless of other Hb variants present.

^dPositive predictive value.

^eNegative predictive value.