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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Metab Brain Dis. 2018 Jun 18;33(5):1599–1607. doi: 10.1007/s11011-018-0266-7

Fig. 4. Anti-inflammatory macrophages are decreased in the spleen and increased in the spinal cord of ABX pretreated mice.

Fig. 4

In the spleen there was a significant decrease (p<0.001) in the frequency of CD11b+ Arg-1+ cells (A) in ABX treated mice (n=7) compared to control mice (n=5) and there was a corresponding significant increase (p<0.01) in the relative expression of Arg1 in the spinal cords of ABX treated mice (n=3) compared to controls (n=3; B). The frequency of CD11b+ CD206+ cells was unchanged in the spleen (D), although there was a significant decrease (p<0.01) in the relative expression of CD206 in the spinal cords of ABX mice compared to controls (E). Markers of pro-inflammatory microglia/macrophages in the spinal cords of ABX pretreated mice were significantly decreased (p<0.01) compared to controls, notably the relative expression of TNFα and iNOS (C and F) respectively