Skip to main content
. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: J Allergy Clin Immunol. 2018 Jun 18;143(2):619–630.e7. doi: 10.1016/j.jaci.2018.05.032

Figure 1. EC sensitization elicits a systemic IL-22 response and an antigen-specific IL-22 response in the lungs.

Figure 1

A-B. IL-22 secretion by OVA stimulated splenocytes (A) and IL-22 serum levels (B). C,D. Il22 mRNA expression in the lungs (C), and IL-22 secretion by OVA stimulated lung cells (D). E. Representative FACS analysis and quantitation of intracelluar expression of IL-22+ cells among CD3+CD4+ T cells and of IL-17A+ and TNFα+ cells among CD3+CD4+IL-22+ cells in the lung. Mice were EC sensitized with OVA or saline in A and B, followed by i.n. challenged with OVA in C-F. Bars represent mean±SEM (n=5–10 per group). *p<0.05.