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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: J Allergy Clin Immunol. 2018 Jun 18;143(2):619–630.e7. doi: 10.1016/j.jaci.2018.05.032

Figure 5. Th22 antigen-specific CD4+ T cells drive neutrophil-dominated airway inflammation and AHR in response to intranasal antigen challenge.

Figure 5

A. Cytokine secretion by vitro polarized Th22 cells from in WT and Il22−/− mice. B-F. Total and differential cell counts in BALF (B), frequency of neutrophils in lungs (C), H&E stained lung sections (D), chemokine mRNA levels in lungs (F), and lung resistance in response to increasing doses of methacholine (G) in WT recipients of Th22 polarized OVA-specific CD4+ T cells from DO11.10 and DO11.10/Il22−/− mice following n. challenge with OVA. Mice that received no T cells were used as controls. Bars represent mean±SEM (n=4–6 per group). *p<0.05, **p<0.05, ***p<0.001.