Table 1.

Participant numbers and study follow-up for each primary drug: side effect cohort (Models 1–3)

	Metformin – GI	SU – hypo	TZD – edema	TZD – fracture
Number of participants	1,200	1,052	1,241	1,311
Number of events (%)	440 (37%)	270 (26%)	164 (13%)	88 (7%)
Baseline HbA1c (%)	7.3 (6.7; 7.9)	7.3 (6.7; 7.9)	7.3 (6.7; 7.9)	7.3 (6.7; 7.9)
Number of recorded HbA1c	13 (6; 19)	12 (5; 19)	18 (9; 20)	18 (10; 21)
Study follow-up (years)	2.8 (1.0; 4.2)	2.5 (0.9; 4.2)	4.0 (1.8; 4.7)	4.0 (2.1; 4.7)

Note: Data are median (IQR) unless stated (refer Table S4 for participants included in Model 4).

Abbreviations: GI, gastrointestinal; SU, sulfonylurea; TZD, thiazolidinedione.