Table 6. Analysis of Diagnosis and Treatment Options of Lennox-Gastaut Syndrome.
Clinical Features | Specification | History of West syndrome (n=13) | No History of West syndrome (n=27) | p value |
---|---|---|---|---|
Seizure type | Tonic | 7 (53.8) | 7 (25.9) | 0.085 |
Focal | 3 (23.1) | 10 (37.0) | 0.305 | |
Tonic-clonic | 3 (23.1) | 10 (37.0) | 0.305 | |
Myoclonic | 3 (23.1) | 9 (33.3) | 0.391 | |
Atonic | 3 (23.1) | 9 (33.3) | 0.391 | |
Absence | 1 (7.7) | 6 (22.2) | 0.254 | |
Clonic | 0 (0) | 2 (7.4) | 0.450 | |
Other | 8 (61.5) | 3 (11.1) | 0.002 | |
Electroencephalography | Background rhythm | |||
Slow and disorganized background | 13 (100) | 27 (100) | - | |
Focal slowing | 3 (23.1) | 5 (18.5) | 0.521 | |
Epileptiform discharges | ||||
GPFAs | 10 (76.9) | 10 (37.0) | 0.018 | |
GSSW | 7 (53.8) | 16 (59.3) | 0.504 | |
Focal sharp/spike waves | 0 (0) | 6 (22.2) | 0.077 | |
Multifocal sharp/spike waves | 11 (84.6) | 16 (53.9) | 0.105 | |
Seizure frequency | At the time of diagnosis | 283.2±469.4 | 118.6±150.8 | 0.103 |
1 year after diagnosis | 321.9±808.7 | 59.7±105.5 | 0.266 | |
Last visit after diagnosis | 125.0±179.2 | 32.0±93.7 | 0.042 | |
Reduction rate (1 yr after diagnosis) | ||||
Seizure-free | 0 (0) | 7 (25.9) | 0.074 | |
Reduction ≥50% | 7 (53.8) | 9 (33.3) | 0.185 | |
Reduction <50% | 1 (7.7) | 1 (3.7) | 0.550 | |
Aggravation | 5 (38.5) | 10 (37.0) | 0.599 | |
Reduction rate (last visit) | ||||
Seizure free | 1 (7.7) | 10 (37.0) | 0.060 | |
Reduction ≥50% | 8 (61.5) | 10 (37.0) | 0.207 | |
Reduction <50% | 1 (7.7) | 1 (3.7) | 0.573 | |
Aggravation | 3 (23.1) | 4 (14.8) | 0.058 | |
Antiepileptic drugs | At the time of diagnosis | 2.7±1.3 | 2.7±1.4 | 0.979 |
1 year after diagnosis | 3.9±1.1 | 3.2±1.3 | 0.093 | |
Last visit after diagnosis | 4.3±1.0 | 3.4±1.8 | 0.058 | |
Ketogenic diet | Yes | 9 (69.2) | 15 (55.6) | 0.503 |
Retention rate | ||||
Retention ≥6 mon | 7/9 (77.8) | 7/15 (46.7) | 0.082 | |
Retention <6 mon | 2/9 (22.2) | 8/15 (53.3) | 0.082 | |
Epilepsy surgery | Yes | 0 (0) | 4 (14.8) | 0.192 |
GPFA, generalized paroxysmal fast activity; GSSW, generalized slow spike wave.
Data are given as mean±standard deviation or number (percentage).