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. 2018 Dec 13;60(1):106–114. doi: 10.3349/ymj.2019.60.1.106

Table 6. Analysis of Diagnosis and Treatment Options of Lennox-Gastaut Syndrome.

Clinical Features Specification History of West syndrome (n=13) No History of West syndrome (n=27) p value
Seizure type Tonic 7 (53.8) 7 (25.9) 0.085
Focal 3 (23.1) 10 (37.0) 0.305
Tonic-clonic 3 (23.1) 10 (37.0) 0.305
Myoclonic 3 (23.1) 9 (33.3) 0.391
Atonic 3 (23.1) 9 (33.3) 0.391
Absence 1 (7.7) 6 (22.2) 0.254
Clonic 0 (0) 2 (7.4) 0.450
Other 8 (61.5) 3 (11.1) 0.002
Electroencephalography Background rhythm
 Slow and disorganized background 13 (100) 27 (100) -
 Focal slowing 3 (23.1) 5 (18.5) 0.521
Epileptiform discharges
 GPFAs 10 (76.9) 10 (37.0) 0.018
 GSSW 7 (53.8) 16 (59.3) 0.504
 Focal sharp/spike waves 0 (0) 6 (22.2) 0.077
 Multifocal sharp/spike waves 11 (84.6) 16 (53.9) 0.105
Seizure frequency At the time of diagnosis 283.2±469.4 118.6±150.8 0.103
1 year after diagnosis 321.9±808.7 59.7±105.5 0.266
Last visit after diagnosis 125.0±179.2 32.0±93.7 0.042
Reduction rate (1 yr after diagnosis)
 Seizure-free 0 (0) 7 (25.9) 0.074
 Reduction ≥50% 7 (53.8) 9 (33.3) 0.185
 Reduction <50% 1 (7.7) 1 (3.7) 0.550
 Aggravation 5 (38.5) 10 (37.0) 0.599
Reduction rate (last visit)
 Seizure free 1 (7.7) 10 (37.0) 0.060
 Reduction ≥50% 8 (61.5) 10 (37.0) 0.207
 Reduction <50% 1 (7.7) 1 (3.7) 0.573
 Aggravation 3 (23.1) 4 (14.8) 0.058
Antiepileptic drugs At the time of diagnosis 2.7±1.3 2.7±1.4 0.979
1 year after diagnosis 3.9±1.1 3.2±1.3 0.093
Last visit after diagnosis 4.3±1.0 3.4±1.8 0.058
Ketogenic diet Yes 9 (69.2) 15 (55.6) 0.503
Retention rate
 Retention ≥6 mon 7/9 (77.8) 7/15 (46.7) 0.082
 Retention <6 mon 2/9 (22.2) 8/15 (53.3) 0.082
Epilepsy surgery Yes 0 (0) 4 (14.8) 0.192

GPFA, generalized paroxysmal fast activity; GSSW, generalized slow spike wave.

Data are given as mean±standard deviation or number (percentage).