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P2 receptor pharmacology used
| Target receptor | IC50/EC50 | Applied concentrations | |
|---|---|---|---|
| P2 Receptors Agonists | |||
| αβmeATP | Most P2X (P2X4 in high concentrations) | > 100 μM for P2X4; 0.5 μM for other P2X | 50–400 μM |
| P2 Receptors Antagonists | |||
| 5-BDBD | P2X4 | 0.50 μM | 10 μM |
| NF 449 | P2X1/P2X1/5/P2X2/3/P2X3/P2X2/P2X4 | 0.28 nM/0.69 nM/120 nM/1820 nM/47 μM/300 μM | 40 μM |
| AZ10606120 | P2X7 | 20 nM | 10 μM |
| isoPPADS | non-selective P2X antagonist, affects P2Y (>IC50 ~ 0.9 mM) | 1–2.6 μM | 20 μM |
