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a–e Changes in body weight, fasting insulin, fasting blood glucose, insulin resistance, and paw withdrawal threshold of rats subjected to a high-fat, high-sugar diet for 7 weeks and a single intraperitoneal injection of STZ in a dose of 35 mg/kg at 5 W. Data were presented as the mean ± SD and analyzed using independent sample t test. n = 8 for the control group and n = 16 for the PDN modeling group. ∗∗P < 0.01, compared with the control group
