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Braak and Braak stage: this approach evaluates primarily the distribution of neurofibrillary tangles (NFT) within the brain (modified from The National Cell Repository for Alzheimer’s Disease, NCRAD)
| Stage | NFT distribution | Typical clinical impression |
|---|---|---|
| I/II | Entorhinal | Normal cognition |
| III/IV | Limbic | Cognitive impairment |
| V/VI | Neocortical | Alzheimer’s disease |
