Table 4.
IC50 and pIC50 ± SEM values of cisplatin achieved from combination treatment of adenosine and cisplatin in the presence or absence of 10 μM dipyridamole. Adenosine at 500 μM concentration was pre-incubated for 48 h prior to 72 h co-incubation with increasing concentrations of cisplatin in the presence or absence of 10 μM dipyridamole. Data shown are representative data from at least three independent experiments. (*) and (#) indicate statistical significance compared to cisplatin alone (control) and cisplatin plus adenosine, respectively (P value < 0.05)
| Cell lines | IC50 (μM) | ||
|---|---|---|---|
| (pIC50 ± SEM) | |||
| Control | + Adenosine | + Dipyridamole | |
| + Adenosine | |||
| A2780 | 5.11 | 2.88* | 4.86# |
| (5.29 ± 0.04) | (5.54 ± 0.04) | (5.31 ± 0.04) | |
| A2780CisR | 32.4 | 20.8* | 33.1# |
| (4.49 ± 0.06) | (4.68 ± 0.05) | (4.48 ± 0.06) | |
| HEY | 5.89 | 2.45* | 4.26# |
| (5.23 ± 0.03) | (5.61 ± 0.04) | (5.37 ± 0.03) | |