Figure 1. The IL-20 receptor cytokines and their receptors.
IL-19, IL-20 and IL-24 signal through the heterodimeric receptor, IL-20RA/IL-20RB complex. In addition, IL-20 and IL-24 have another heterodimeric receptor, which composed of IL-22RA1 and IL-20RB. Both receptors signal through the STAT-JAK signaling pathway.