Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Dec 18;8:17935. doi: 10.1038/s41598-018-36287-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Minimum recording duration to categorize data as epileptic vs. control is between 7 and 14 minutes or about 10 seizures. Neocortical oxygen data was binned as displayed and filtered for fast oxygen dynamics (>0.08 Hz). We computed the differences in group means (a) or between the lowest point in the GAERS group from the highest point in the NEC group (b), such that a positive value in (b) would indicate that there is no overlap between groups. (a) Binning data into shorter epochs did not dramatically alter the differences in group means. (b) Binning data into shorter epochs resulted in the appearance to negative values, indicating that the group distributions started to overlap (i.e. highest value in the NEC group was greater than the lowest of the GAERS group). (c) Data from (b) plotted against the corresponding number of seizures (mean across rats) for that bin and fitted to a sigmoidal curve. The curve crossed from negative to positive values at 9.6 seizures per rat.