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. 2018 Dec 18;8:17924. doi: 10.1038/s41598-018-36394-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ribbon representation of VEGFB-VEGFR1 D2 complex (A), VEGFA-VEGFR2 D2 complex (B) and schematic representation of the structure of VGB4 peptide (C). Individual segments are highlighted in different colors: VEGFR1 D2 and VEGFR2 D2 are represented in blue whereas VEGF monomers are colored in green. The interacting regions in VEGFB-VEGFR1 D2 complex are colored in red and yellow. The interacting region in VEGFA-VEGFR2 D2 complex is colored in violet. The Figure was made using the software PyMOL (PYMOL Molecular Graphics System, Version 2.1 Schrödinger, LLC).