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. 2018 Dec 18;8:17924. doi: 10.1038/s41598-018-36394-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The investigation of the tumor-accumulating ability of VGB4 using 2D optical imaging. (A) After intravenous VGB4-FITC injection into BALB/c mice bearing 4T1 murine MCT, the whole body of each mouse was scanned at 0, 30, 60 and 90 minutes after injection. (B) The fluorescence intensity (in tumor region) at different times (0, 30, 60 and 90 minutes) after injection was compared to control group (untreated animals). The experiment was repeated three times. **P ≤ 0.001, compared to the control group.