Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 10;23(11):2156–2166. doi: 10.1038/mp.2017.156

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if thematerial is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Regulation of claudin-5 levels by anti-psychotic drugs and examples of aberrant claudin-5 expression in schizophrenia. (a) Levels of expression of claudin-5 in primary mouse brain endothelial cells exposed for 24 h to lithium (LiCl), haloperidol (HAL) or chlorpromazine (CPZ). (b) Immunocytochemical analysis of claudin-5 (red)-staining pattern in primary mouse brain endothelial cells treated with anti-psychotic drugs; scale bar: 50 μm. (c) Levels of expression of claudin-5 in capillary fractions from mouse brains 24 h following administration (i.v.) of LiCl, HAL or CPZ. (d) Claudin-5 expression was significantly higher in mice treated with antipsychotics (*P<0.05). (e) Claudin-5 mRNA levels were significantly higher in mice treated with CPZ (*P<0.05). (f) Claudin-5 levels in normal control or schizophrenia donor brain tissues from the parietal lobe. Sixty-two per cent of schizophrenia patients showed aberrant claudin-5 staining in the parietal lobe. (g) There are significantly lower levels of claudin-5 in the parietal lobe in individuals who have a diagnosis of schizophrenia and the presence of the rs10314 allele compared to controls who have the rs10314 allele (*P<0.05).