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. 2018 Dec 18;8:17926. doi: 10.1038/s41598-018-36159-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Recorded oxygen (O₂) profile: Recorded O₂ profile alternating between 10% and 21% every 5 min under chronic intermittent hypoxia condition in the chamber of an in vivo study. (B) Kidney tissue NE levels after RD: RD(−) mice show significantly higher kidney tissue NE levels compared with RD(+) mice. Kidney tissue NE levels of mice subjected to RD are almost undetectable. **P < 0.01 [RD(−) + CIH vs. RD(+) +CIH]. (C) Protocol: We divided the mice into three groups: (1) Control in %O₂ 21% (n = 21), (2) CIH (n = 22), and (3) RD/CIH (n = 13).