Figure 1.

(A) Schematic figure of the IgG molecule and location of the Fc-glycans. Two common N-linked Fc-glycans, the digalactosylated (FA2G2) and the main agalactosylated form (FA2) are shown linked to the IgG-Fc region. (B) The factors (FA2, sum of afucosylated, Σ[aF] and sum of bisected forms Σ[B]) that were shown to affect the Fc-glycan profile of IIM or phenotype specific IIM most prominently. The glycan nomenclature is according to Royle et al.⁴⁴. Blue squares (N-acetyl-glucosamine), red triangle (Fucose), green circles (Mannose), yellow circles (Galactose) and purple diamonds (Sialic Acid).