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. 2018 Dec 18;8:17938. doi: 10.1038/s41598-018-36041-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Normalized degree centralities of significantly larger (red lines) and smaller (black lines) distances observed in resistant ensembles for 8 FDA-approved protease inhibitor complexes, namely ATV (a), DRV (b), FPV (c), IDV (d), LPV (e), NFV (f), SQV (g) and TPV (h). The top 5 residue positions with the highest connectivities are labelled at the peaks in each graph. Inserted underneath are the functional protease residues depicted as colored dots, namely the fulcrum , the elbow , the flap , the cantilever , the interface and the binding cavity residues .

Inline graphic — Normalized degree centralities of significantly larger (red lines) and smaller (black lines) distances observed in resistant ensembles for 8 FDA-approved protease inhibitor complexes, namely ATV (a), DRV (b), FPV (c), IDV (d), LPV (e), NFV (f), SQV (g) and TPV (h). The top 5 residue positions with the highest connectivities are labelled at the peaks in each graph. Inserted underneath are the functional protease residues depicted as colored dots, namely the fulcrum , the elbow , the flap , the cantilever , the interface and the binding cavity residues .